Standardized High Potency Herb - Herb Extract Mary Thistle (Silybum marianum). Vegicaps each containing 175 mg of standardized-grass seed (80% silymarin) and 300 mg of powder extract. Dosage: Both forms: As a herbal supplement for feeding adults, 1-3 vegicaps daily, preferably with meals or as directed by the specialist. USES:-Protector liver. In tests in vitro on hepatocytes has been shown that silymarin has a protective effect against carbon tetrachloride or toxin from Amanita phalloides phalloidin. This effect seems to be due to an alteration of membrane permeability, preventing access to toxins into cells. Moreover silibinin decreases the activity of Kupffer cells (decreasing production of superoxide radicals, nitric oxide and leukotrienes) and the production of glutathione, further decreasing oxidation. Silymarin acts in vitro assays as regenerating liver. Increases protein synthesis in hepatocytes by stimulating the activity of RNA polymerase I-Anti-inflammatory. Silymarin has an inhibitory effect on the synthesis of leukotrienes by inhibiting 5-lipoxygenase (5-LOX). -Lipid. It has also proven to silymarin in rat tests certain hypolipidemic effect, lowering the cholesterol content in the liver and increasing HDL-C.
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