Standardized extract of Hipérico in polvo(1,1 mg [ 0.3% ] of hipericina)...,300 mg Hipérico in Phyt02X dust? (it mixes in dust of betacarotenos and,100 acid ascórbico)... mg Phyt02X? it is a special combination of antirust natural whose function is to maintain the freshness of the ingredients. The capsules contain the following natural ingredients: vegetal magnésico estearato. Vegetal capsule: cellulous metil hidroxipropil. Before taking this product - If he is taking other medicines, his doctor or phamacist consults with, since the Hipérico could affect its action. The use of higher doses of Hipérico can give rise to a fotosensibilidad reaction. Ask and a specialist which are the suitable doses. She does not have to take itself with foods that contain tiramina as they are the cheeses and the cured meats. ACTIVITY FARMACOLOGICA OF THE HIPERICO. Therapeutic classification: PN03. Antidepressing medicinal plants. Antidepressant. In tests in alive on rat the antidepressing activity of the hipérico extract has been verified, with an increase of the locomotive activity and the ansiolítico effect. This activity is attributed to floroglucínicos compounds, to naftodiantronas and xantonas. The antidepressing action is not pronounced until at least two weeks after beginning the treatment. The activity mainly seems to have to an interaction with the GABA-érgico systems and serotoninérgico by blockade of the recaptación of serotonin and other neurotransmitters (dopamine, noradrenaline). Also it has been postulated that the antidepressing effect must partially to an inhibition of monoamino-oxidasa To and B (MAO To and B) and of catecol-o-metil-transferasa (COMT), enzymes responsible for the catabolism of biógenas amines. In clinical tests it has been verified that its effectiveness is equivalent to the one of tricyclic antidepressants in the average or moderate depression, but that is little effective in the severe depression. Ansiolítico. It seems to be that the benzodiazepínico receiver is implied in the activation of the ansiolítico effect of the hipérico extract. Hipnótico. The hipérico produces a depression of the central nervous system.