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Lasix, with the active ingredient furosemide, is a potent and fast-acting diuretic. It belongs to a class of drugs known as sulfonamide derivatives. Its primary function is to help your body get rid of excess salt and water.
Lasix works by blocking the Na+, K+, Cl- ion transport system in a specific part of the kidney called the thick ascending limb of the loop of Henle. This action prevents the reabsorption of sodium chloride, leading to its diuretic effect. As a result, there is an increase in urine output (due to osmotically bound water) and enhanced secretion of potassium in the distal renal tubules. The drug also increases the excretion of calcium and magnesium ions. The effectiveness of furosemide can be reduced if its secretion into the renal tubules is decreased or if it binds to albumin within the tubules.
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In patients with heart failure, Lasix rapidly reduces cardiac preload by dilating veins, which in turn lowers pulmonary artery pressure and left ventricular filling pressure. This quick effect is mediated by prostaglandins, requiring normal prostaglandin synthesis and adequate kidney function. The drug also has a hypotensive (blood pressure-lowering) effect. This is achieved by increasing sodium excretion, reducing the volume of circulating blood, and decreasing the response of vascular smooth muscles to vasoconstrictors. This reduced vascular response is due to the natriuretic effect of furosemide, which lessens the impact of catecholamines, often elevated in hypertensive patients. The diuretic and natriuretic effects are dose-dependent, typically observed with doses ranging from 10 mg to 100 mg. Following a 20 mg intravenous dose, the diuretic effect begins within 15 minutes and lasts for approximately 3 hours.
The volume of distribution for furosemide is 0.1-0.2 L/kg of body weight, which can vary based on the patient's underlying medical conditions. Furosemide is highly bound (over 98%) to plasma proteins, primarily albumin. It is excreted mainly unchanged through secretion in the proximal tubules of the kidneys. After intravenous administration, about 60-70% of the dose is eliminated this way. Glucuronidated metabolites of furosemide make up 10-20% of the drug excreted by the kidneys. The remainder of the dose is eliminated through the intestines, likely via biliary secretion.
Lasix is prescribed for the treatment of:
You should not take Lasix if you have any of the following conditions:
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Order Lasix NowPlease read carefully: The information provided on this page is a brief summary and is for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read here. While it is possible to buy Lasix online, self-treatment can be dangerous to your health.
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